Joe Rogan: Welcome back to the number one podcast in the world.
The latest is, hot off the press as of yesterday, the administration is still working diligently to reclassify peptides. That got unveiled on the podcast. That has been a labor of love for the last two and a half, three years.
And I know I said this when I was on here six months ago, but I'm truly the most optimistic I've ever been and with reason. I want to like temper expectations, but you know, the prior administration of the FDA put these things into place prior to Secretary Kennedy and this administration taking over. It was almost like a Trojan horse. They just planted this little bomb in the middle of everything and classified these peptides as dangerous.
I submitted 17 FOIA requests, 17 to the FDA. They have never once responded to a single FOIA request just asking for clarity about safety and why did we make this decision and they're supposedly by law required to respond to this request.
So to go from that environment where you're being stonewalled and you have no accessibility and no line of sight and no answers to anything to being able to at least have a seat at the table and a voice is pretty revolutionary.
Joe: Well, it's just very helpful that Kennedy uses them, that Kennedy uses them and he knows the benefits of them and he's very educated on it. That helps a lot.
Brigham: Someone who is actually fit, takes care of himself and uses peptides and understands what millions of people know. I mean, there's millions of people right now that are taking peptides and it's radically improved their health and their vitality.
Joe: Could you please expand on the testosterone thing? Because one of the things that keeps coming up with people when I talk to friends that are older and I say, "Hey, you know, you should probably get your hormone levels checked and consider getting on TRT or at the very least getting on something like hCG. That can increase your testosterone. It'll really vitalize your health." They get concerned with prostate cancer.
All of the fear with prostate cancer literally comes from a study from the 1930s and it was a urologist in the 1930s. The patient population of this study when we talk about random control trials, there were three patients in the study. One patient dropped out, one patient was chemically castrated, the other patient was normal.
So the chemically castrated patient meaning they have no testosterone. So if you treat a patient who has no testosterone and you take them from zero testosterone to normal testosterone. So to take them from let's say zero to 350 during that climb from 0 to 350 you can increase in theoretically the risk of exasperating a prostate cancer that's pre-existing was the fear.
But as you push past that level to optimal levels, you begin to insulate against the risk of multiple cancers. And all of the studies henceforth have shown there is not one single study that correlates testosterone therapy to prostate cancer.
Here's a really real world example with the boom in testosterone therapy. If there was an increased risk in prostate cancer due to hormones, you would have seen a skyrocket in the amount of prevalence of prostate cancer and all of these practices that are using hormone optimization. You don't see the same prevalence that we saw prior to hormone optimization and the boom.
Joe: So this initial study like why was the one person chemically castrated?
Brigham: I don't know why this is in the 30s but since then here's a really real world example with the boom in testosterone therapy. If it was exasperating prostate cancer you would have seen it then too. And so now, retrospectively, a hundred years later, literally a hundred years later, the FDA and our regulatory oversight bodies are now changing their lens on men and women's HRT.
The FDA has come to the consensus under this new leadership that that is the case. And they are working to remove the blackbox warning on hormones. They are working to remove the fear-mongering around women's hormones and the women's health initiative and all these things because we now know what we've been preaching for almost a decade is that these hormones are a crucial building block that allow us to drive health span and a lot of the decline that we see in our body is because of the hormonal decline that occurs in our 40s and 50s.
Brigham on Medical Dogma: What Marty is saying is dogma and that medicine is so worried about defending their principles and where they stand that they're essentially ignoring at times science and they're allowing dogma to rule the day rather than letting a pragmatic like authentic open-minded view change your perspective and lens on topics.
It's confusing dogma with consensus. When everyone group think is dangerous when it is considered consensus because group think isn't necessarily consensus it's peer pressure to adopt the values and belief systems of your peers in academia and there's an immense amount of pressure to not stray from the herd to stay within the herd to back your peers to tow the line.
I was the typical American patient. I was on the cusp of diabetes. I was obese. I'm a former fat kid, you know, like everything that could be going wrong in my late 30s was going wrong because I had bought into the system and trusted the system and thought, hey, if I get my blood work annually and I follow the doctor's rules, you know, the system's just not built that way.
Three Healthcare Pathways:
1. Traditional System β Insurance-based, reactive treatment, not patient-centered
2. High-End Concierge Care β Hundreds of thousands per year, accessible only to the top 0.01% (e.g., Peter Attia model)
3. Pill Mills (HIMS Model) β Low-cost prescriptions, monetize patients first, quality second
How do we combine the best of both worlds? Nuanced concierge care that's affordable, scalable, and truly drives health span. The root of all evil. When you put money above everything else, that's the problem. If we always make it about people, money will follow. Our North Star is people, profit is secondary.
Differentiation:
β’ Large Language Models (LLMs) β Diagnostic assistance
β’ Wearables Integration β Real-time health tracking
β’ Smart Scale β DEXA-level accuracy (1-2% margin of error)
- Visceral fat, subcutaneous fat, muscle mass tracking
β’ Blood work + integrated dashboard
Blood work is just one marker in the ocean. One diagnostic tool in the sea of tools. We don't just prescribe medication and finish. We become a copilot, optimizing together.
β’ Smaller than conventional MSCs β Can cross blood-brain barrier
β’ Intranasal administration β Direct delivery to brain
β’ Active in midbrain 18 months later
β’ Potential treatment: Parkinson's, Alzheimer's, Dementia
Regulatory Barriers: US: Still limited, Overseas: Widely used. New administration: Improving regulatory pathways for peptides, stem cells, cash-pay products.
Natural substances that can't be patented β Should they require multi-billion dollar regulatory processes? Big Pharma has no interest in treatments they can't monetize through patents.
Used for 50+ years (Mayo Clinic, major academic institutions). Traditional: Autoimmune diseases, inflammatory conditions. New: Longevity & preventive medicine.
How It Works:
1. Blood passes through dialysis machine
2. 70% of inflammatory markers and waste products in plasma removed
3. Replaced with young, healthy albumin
Waste to Well's Additional Protocol:
β’ Add MSC stem cells
β’ Peptide supplementation
β’ Fortify albumin with missing nutrients
"Your body's oil change" β Remove 70% of the gunk accumulated over 45 years. Alzheimer's & dementia are highly correlated with inflammation β TPE can prevent.
Use Cases: Inflammatory diseases, Alzheimer's & dementia (high inflammation correlation), Preventive health optimization (45-year-old male case)